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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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Azido-PEG3-C3-OH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This click chemistry reagent features an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It also supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG3-Aminooxy is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs feature two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest. This product is intended strictly for research purposes and is not for patient use.
Peg-based PROTAC linker
Used in the synthesis of PROTACs
Facilitates selective degradation of target proteins
For research use only
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NH-bis(PEG3-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules connect two different ligands: one for an E3 ubiquitin ligase and another for a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
PEG-based linker
Essential for PROTAC synthesis
Enables targeted protein degradation
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NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker that belongs to the polyethylene glycol (PEG) linker family. It is used in the synthesis of PROTAC (β-NF-JQ1).
PROTAC linker
Can be used in the synthesis of PROTAC (β-NF-JQ1)
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NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Contains two different ligands connected by a linker
Exploits the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
Applicable in cancer and cancer targeted therapy research
Classified as PROTAC linkers
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Tos-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It can also be utilized for the synthesis of 3'-aminooxy oligonucleotides solid supports.
PEG-based PROTAC linker
Can be used in the synthesis of PROTACs
Can be utilized for the synthesis of 3'-aminooxy oligonucleotides solid supports
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Azido-PEG3-C6-Cl is a PEG-based PROTAC linker and click-chemistry reagent containing an azide functional group. It has molecular formula C12H24ClN3O3, molecular weight 293.79 g/mol, and reported purity 95.3%. The product is a colorless to light-yellow liquid supplied in small milligram pack sizes for research use and is stored at -20°C in pure form (stable up to 3 years).
Acts as a PEG-based linker for PROTAC and conjugate synthesis.
Contains an azide group compatible with CuAAC and strain-promoted click reactions.
Reported purity of 95.3% suitable for research applications.
Available in small pack sizes for synthetic and screening workflows.
Stable when stored at recommended temperatures, enabling longer-term storage.
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SX-682 is a potent selective and orally bioavailable inhibitor of CXCR1/2 has the potential to treat castration-resistant prostate cancer. purity: 99%
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(S,R,S)-AHPC-PEG3-NH2 is a VHL E3 ligase ligand-linker conjugate terminating in a primary amine. It is supplied as a research-grade powder for use as a building block in PROTAC synthesis and related chemical biology applications.
VHL-binding motif for targeted protein degradation studies.
Three-unit PEG linker with terminal amine for facile conjugation.
High purity suitable for synthetic applications.
Supplied as a powder convenient for storage and handling.
Store and handle per the manufacturer's datasheet recommendations.
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m-PEG5-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands: one for an E3 ubiquitin ligase and another for the target protein.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system
Selectively degrades target proteins
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Calcein tetraethyl ester, also known as Fluorexon tetraethyl ester, is a fluorescent dye utilized in biological applications. Its key characteristic is its ability to be transported through the cellular membrane into live cells. This property makes it valuable for assessing cell viability and for the short-term labeling of cells.
Effective for live cell studies: Its cell-permeable nature allows for direct application in living systems without damaging cell integrity.
Versatile in research: Can be used for various analyses including cell function, in vivo imaging, and cell staining.
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